alpha;-酮戊二酸在生理过程中的生物学作用及其治疗潜力摘 要：在本文中，我们介绍了最近关于alpha;-酮戊二酸（AKG）在包括发育期的动物中的作用机制和生物学作用的研究结果。
AKG是三羧酸循环中的中间产物，它为生命过程产生能量。
AKG的应用已被证明有利于年轻生物生长期以及成年期的骨骼系统的正常发育和功能。
在作为膳食补充剂的形式下，它也有助于抑制女性骨质疏松症。
此外，它还能促进肌肉的生长并加速伤口愈合。
AKG对健康动物和胃肠道粘膜受损动物的胃肠道形态有显著影响。
因为它刺激肠道形态的有益改变，它也是有治疗短肠综合征患者前景的物质。
最近的研究也显示AKG具有神经保护作用。
关键词：alpha;-酮戊二酸；谷氨酰胺；膳食补充剂；肠道吸收THE BIOLOGICAL ROLE OF alpha;KETOGLUTARIC ACIDIN PHYSIOLOGICAL PROCESSESAND ITS THERAPEUTIC POTENTIALAbstract：.In this article we present the results of recent studies on the mechanism of action and biological role of alpha;-ketoglutaric acid (AKG) in animals including developmental period of life. AKG is an intermediate in the Krebs cycle, which generates energy for life processes. Administration of AKG has been shown to be beneficial for proper development and function of the skeletal system during growth of young organisms, as well as in adulthood. In the form of a dietary supplement it also contributes to inhibition of osteoporosis in women. Moreover, it promotes the growth of muscle mass and accelerates wound healing. AKG has a significant impact on the morphology of the gastrointestinal tract in healthy animals and animals with damaged gastrointestinal tract mucosa. It is also a promising substance for the treatment of patients with short bowel syndrome, as it stimulates beneficial changes in intestinal morphology. Recent research has also revealed that AKG has neuroprotective effects. Key words: alpha;-ketoglutaric acid, glutamine, dietary supplements, intestinal absorption1.AKG的生物合成早alpha;-酮戊二酸是一种含有羧基和酮基的有机化合物。
