脂凋亡在酒精性脂肪肝中的作用及机制研究进展
摘 要：酒精性脂肪肝（alcoholic fatty liver disease, AFLD）是过量饮酒引起的肝细胞损伤性疾病，表现为肝细胞反复发生脂肪变性、坏死。脂肪变性指非脂肪细胞脂类超负荷，可造成脂毒性和脂凋亡,最终发展为肝炎和肝硬化。本文系统阐述脂凋亡在AFLD中起到的关键作用，对近年来关于脂凋亡在AFLD中的作用及机制研究进行全面综合、整理和归纳。脂凋亡参与AFLD发生发展的各个阶段，抑制脂凋亡可能是目前治疗脂肪肝疾病的有效策略，有助于指导治疗脂肪肝药物靶点的筛选，为抗AFLD研究及药物研发提供新的视角。
关键词：酒精性脂肪肝；脂毒性；脂凋亡; 脂肪代谢; 内质网应激
Abstract: Alcoholic fatty liver disease (AFLD) is a term that encompasses the liver manifestations of alcohol overconsumption, including steatosis, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis. steatosis is acknowledged as non-fat cell lipid overload, leading to lipid apoptosis. The role of lipid apoptosis in AFLD in recent years was comprehensively summarized. It was considered as an effective strategy for the treatment of fatty liver diseases via reducing the lipid apoptosis. It is expected to be an effective target for the prevention of AFLD, which could be used for fatty liver disease drug screening.
Key Words: Alcoholic fatty liver disease; Lipid toxicity; Lipid apoptosis; Lipid metabolism; Endoplasmic reticulum stress
