黄酮类环糊精包合物的制备与结构表征的研究
摘 要
随着人类对高效且安全的天然药物需求的增长，植物类药物活性单体的研究受到广泛的关注。黄酮类物质因其独特的骨架结构和生理活性，在生命科学中地位极高。本文选用的穗花杉双黄酮是一种具有多种生物活性的化合物，其在抗炎、抗氧化、抗肿瘤及神经保护方面具有较好的作用及较高的研究价值。但黄酮类物质水溶解性较差，受热不稳定，需要一种高效低毒的载体使其适用于实际。环糊精具有外缘亲水而内腔疏水的结构性质，是构筑各种功能材料的优良结构单元。同时，环糊精是一种近于酶的理想宿主分子，可以识别分子形成主客体包合物。主要包括固载化环糊精的药物的缓释与负载、污染物吸附、表面功能化的应用。因此，黄酮类环糊精形成包合物能弥补黄酮类物质的缺陷。本文主要介绍了当前穗花杉双黄酮与环糊精的制备方法与研究进展，为环糊精穗花杉双黄酮包合物的制备与结构表征做准备，并为之后环糊精穗花杉双黄酮包合物的抗氧化抗肿瘤性能的深入研究奠定基础。
关键词：穗花杉双黄酮；环糊精；包合物；制备；结构表征
Progress of the preparation and characterization of the flavonoids-cyclodextrin compounds
ABSTRACT
With the growth of the demand for effective and safe natural drugs, the research of the active monomer of plant drugs has been drawn wide attention. Flavonoids are in high position in the life science because of their unique skeleton structure and physiological activity. Amentoflavone is a multi-bioactive compounds, which has considerable research value and extraordinary functions of anti-inflammation, anti-oxidation, anti-tumor and neuroprotection. Nevertheless, the flavonoids have properties of indissolubility in water and instability with heat, the flavonoids need a vector with efficient and low toxicity to make it suitable for the application. The Cyclodextrin (CD) has hydrophilic outer and hydrophobic inner, which makes CD excellent structural units to construct various functional materials. Meanwhile, CD likes the enzyme which approximates to ideal host molecules that can identify the molecular to form host-guest inclusion compound. The current application of the immobilized CD includes drug releasing and loading, the adsorption of pollutants and surface functionalization. Thus, the flavonoids-CD inclusion compound can make up for the defect of flavonoids. This paper mainly illustrates the current research progress and preparation methods of amentoflavone and CD, which serves the preparation and characterization of the amentoflavone-CD inclusion compound. Furthermore, this paper lays a foundation for further research of anti-oxidant and anti-tumor properties of the amentoflavone-CD inclusion compound.
Key words: Amentoflavone; Cyclodextrin; Inclusion compound; Preparation; Characterization
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